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The following
clinical presentations of Celiac Sprue:
- Definite Associations:
- Dermatitis Herpetiformis
- IgA deficiency
- Type 1 diabetes
- Autoimmune thyroid disease
- Sjogren’s syndrome
- Microscopic Colitis
- Rheumatoid arthritis
- Down’s syndrome
- IgA nephropathy
Possible associations:
- Congenital heart disease
- Recurrent pericarditis
- Sarcoidosis
- Cystic fibrosis
- Fibrosing alveolitis
- Lung cavities
- Pulmonary hemosiderosis
- Inflammatory bowel disease
- Autoimmune hepatitis
- Primary biliary cirrhosis
- Addison’s disease
- Systemic lupus erythematosus
- Vasculitis
- Polymyositis
- Myasthenia gravis
- Schizophrenia
- Complications:
- Refractory sprue
- Enteropathy associated T-cell lymphoma
- Carcinoma of the oropharynx, esophagus, and small bowel
- Ulcerative jejunoileitis
- Collagenous sprue
- Common Features:
- Adults- Iron deficieny anemia, Diarrhea
- Children- Diarrhea, Failure to thrive, Abdominal distention
Less Common Features:
- General Features – Short Stature, delayed puberty
- Gastrointestinal Features – Recurrent aphthous stomatitis, recurrent
- abdominal pain, steatorrhea
- Extraintestinal Features-
- Folate-deficiency anemia
- Osteopenia or osteoporosis
- Dental-enamel hypoplasia
- Vitamin K deficiency
- Hypertransaminasemia
- Thrombocytosis (hyposplenism)
- Arthralgia or arthropathy
- Polyneuropathy
- Ataxia
- Epilepsy (with or without cerebral calcification)
- Infertility
- Recurrent abortions
- Anxiety and depression
- Follicular keratosis
- Alopecia
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