Conditions associated with Celiac Disease

The England Journal of Medicine (Vol. 346, No. 3, 1/17/02)
  The following clinical presentations of Celiac Sprue:
  • Definite Associations:
  • Dermatitis Herpetiformis
  • IgA deficiency
  • Type 1 diabetes
  • Autoimmune thyroid disease
  • Sjogren’s syndrome
  • Microscopic Colitis
  • Rheumatoid arthritis
  • Down’s syndrome
  • IgA nephropathy

Possible associations:

  • Congenital heart disease
  • Recurrent pericarditis
  • Sarcoidosis
  • Cystic fibrosis
  • Fibrosing alveolitis
  • Lung cavities
  • Pulmonary hemosiderosis
  • Inflammatory bowel disease
  • Autoimmune hepatitis
  • Primary biliary cirrhosis
  • Addison’s disease
  • Systemic lupus erythematosus
  • Vasculitis
  • Polymyositis
  • Myasthenia gravis
  • Schizophrenia
  • Complications:
  • Refractory sprue
  • Enteropathy associated T-cell lymphoma
  • Carcinoma of the oropharynx, esophagus, and small bowel
  • Ulcerative jejunoileitis
  • Collagenous sprue
  • Common Features:
  • Adults- Iron deficieny anemia, Diarrhea
  • Children- Diarrhea, Failure to thrive, Abdominal distention

Less Common Features:

  • General Features – Short Stature, delayed puberty
  • Gastrointestinal Features – Recurrent aphthous stomatitis, recurrent
  • abdominal pain, steatorrhea
  • Extraintestinal Features-
  • Folate-deficiency anemia
  • Osteopenia or osteoporosis
  • Dental-enamel hypoplasia
  • Vitamin K deficiency
  • Hypertransaminasemia
  • Thrombocytosis (hyposplenism)
  • Arthralgia or arthropathy
  • Polyneuropathy
  • Ataxia
  • Epilepsy (with or without cerebral calcification)
  • Infertility
  • Recurrent abortions
  • Anxiety and depression
  • Follicular keratosis
  • Alopecia

 

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